منابع مشابه
The effects of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes.
We used primary cultures of rat hepatocytes to evaluate the effects of glucocorticoids on insulin-responsive hepatic lipogenesis. The data indicate that hepatocytes incubated for 20 h with dexamethasone (0.1 microM) alone are profoundly resistant to the ability of insulin to stimulate lipogenesis acutely. In contrast, primary cultures of hepatocytes incubated with dexamethasone plus insulin are...
متن کاملShort-term stimulation of lipogenesis by 3,5-L-diiodothyronine in cultured rat hepatocytes.
Short-term effects of 3,5-l-diiodothyronine (T2) on lipid biosynthesis were studied in cultured hepatocytes from hypothyroid rats. A comparison with the effects of T3 was routinely carried out. After T2 addition to cell cultures, a distinct stimulation of fatty acid and cholesterol syntheses, measured as incorporation of [1-14C]acetate into these lipid fractions, was observed. The T2 dose-depen...
متن کاملIncreased lipogenesis in isolated hepatocytes from cold-acclimated ducklings.
Thermogenic endurance and development of metabolic cold adaptation in birds may critically depend on their ability to synthesize and use fatty acids (FA) as fuel substrates. Hepatic lipogenesis and the capacity to oxidize FA in thermogenic tissues were measured in cold-acclimated (CA) ducklings (Cairina moschata) showing original mechanisms of metabolic cold adaptation in the absence of brown a...
متن کاملGlucose, amino acids, and lipogenesis in hepatocytes of Japanese quail.
Hepatocytes were isolated from livers of fed, egglaying Japanese quail (Coutournix mutournix j u p n ica). The cells take up and extensively oxidize lactate and pyruvate and, to a lesser extent, fructose, glycerol, sorbitol, and xylitol. The major products were COZ, glucose, and lipid. Lactate was the best substrate for fatty acid synthesis. Glucose at a concentration of 10 IUM was taken up and...
متن کاملMetabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes
It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42791-9